Differences in clinical chemistry values according to the use of two laxatives for colonoscopy.
Author(s): Jeong S, Lee SG, Kim Y, Park JR, Kim JH
Publication: Clin Biochem, 2014, Vol. 47, Page 1047-51
PubMed ID: 24735685 PubMed Review Paper? No
Purpose of Paper
The purpose of this paper was to determine the effects of laxatives given prior to colonoscopy on 19 clinical chemistry analytes measured in blood.
Conclusion of Paper
Significant differences exceeding the acceptable bias were observed in 9 and 6 of the 19 clinical chemistry analytes when patients received sodium phosphate formulations (NaPs) or polyethylene glycol–electrolyte lavage solutions (PEG–ELSs), respectively, prior to colonoscopy than in control patients (no colonoscopy or drugs). Further breakdown based on patient age led to similar findings, though some differences in significance were noted. Only glucose levels were not affected by either laxative.
Studies
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Study Purpose
The purpose of this study was to determine the effects of 2 different laxatives given prior to colonoscopy on 19 clinical chemistry analytes in blood. Clinical chemistry results were retrospectively compared among 3239 patients given NaPs before colonoscopy, 1279 patients given PEG-ELSs before colonoscopy, and 4848 patients who did not receive colonoscopy preparation. The authors do not specify the timing of blood draw with respect to colonoscopy.
Summary of Findings:
Blood from patients given NaPs prior to colonoscopy had significantly higher inorganic phosphorous (p<0.0001), sodium (p<0.0001), chloride (p<0.0001), creatinine (p<0.0001), uric acid (p<0.0001), cholesterol (p<0.0001), total protein (p<0.0001), albumin (p<0.0001), alkaline phosphate (p=0.0003), aspartate aminotransferase (AST) (p<0.0001), alanine aminotransferase (ALT) (p<0.0001), total bilirubin (p<0.0001), and low-density lipoprotein (LDL) cholesterol (p<0.0001) and lower calcium (p<0.0001), potassium (p<0.0001), blood urea nitrogen (BUN) (p<0.0001), triglycerides (p=0.0391) and high density lipoprotein (HDL) cholesterol (p=0.0228) than control specimens, but only the changes in inorganic phosphorous, calcium, sodium, potassium, chloride, creatinine, total protein, AST and ALT exceeded the acceptable bias. Blood from patients given PEG-ELSs had significantly higher inorganic phosphorous (p<0.0001), sodium (p<0.0001), creatinine (p<0.0001), uric acid (p<0.0001), cholesterol (p<0.0001), AST (p<0.0001), ALT (p<0.0001), total bilirubin (p<0.0001), and LDL cholesterol (p<0.0001) and lower calcium (p=0.0091), potassium (p<0.0001), BUN (p=0.0008), and HDL cholesterol (p=0.0228) than control specimens, but only the bias in inorganic phosphorous, potassium, creatinine, uric acid, AST and total bilirubin exceeded the acceptable bias. When broken down by patient age, trends were the same, but differences in significance and magnitude were observed.
Biospecimens
Preservative Types
- None (Fresh)
Diagnoses:
- Not specified
- Normal
Platform:
Analyte Technology Platform Electrolyte/Metal Clinical chemistry/auto analyzer Small molecule Clinical chemistry/auto analyzer Lipid Clinical chemistry/auto analyzer Steroid Clinical chemistry/auto analyzer Carbohydrate Clinical chemistry/auto analyzer Pre-analytical Factors:
Classification Pre-analytical Factor Value(s) Preaquisition Other drugs None
PEG-ELSs
NaPs
Preaquisition Patient age <50 years
>50 years
Preaquisition Surgical procedure type Colonoscopy
None